 ISSN 1392-0138 ISSN 2029-4174 (online) |
2008 m. Nr. 2 Adiponectin and uric acid in pre-diabetes and early type 2 diabetes mellitus
Background. The aim of our study was to evaluate adiponectin and uric acid level in subjects with pre-diabetes and to compare it with the levels in newly diagnosed type 2 diabetes and healthy subjects. We also studied associations of adiponectin level with various anthropometric measurements, indices of glucose metabolism, insulin resistance and uric acid concentration. Material and methods. The study included 48 individuals with pre-diabetes (IGT), 33 newly diagnosed type 2 diabetes mellitus (DM) subjects, and 68 healthy subjects. Blood samples were analysed for fasting blood glucose, insulin, HbA1C, uric acid and adiponectin. According to BMI control subjects were separated into obese (BMI > = 27) and non-obese (BMI < 27) groups. Results. Mean serum adiponectin levels were not statistically significantly different in IGT and DM groups (11.23 ± 9.72 vs. 9.23 ± 5.61 μg/ml, p = 0.858). Serum adiponectin was significantly lower in IGT group as compared to obese-control group (11.23 ± 9.72 vs. 15.62 ± 10.38 μg/ml, p = 0.004). Comparison of obese and non-obese control groups showed that serum adiponectin level was lower in obese subjects, but the difference was not statistically significant (15.62 ± 10.38 vs. 19.62 ± 12.20 μg/ml p = 0.181). Uric acid concentration did not differ in IGT and DM groups (359.80 ± 95.69 vs. 340.55 ± 95.39 μmol/l, p = 0.249), whereas in obese and nonobese control subjects uric acid concentration was statistically significantly lower. Adiponectin and uric acid showed inverse correlation with indices of central obesity. Analysis of associations between adiponectin and uric acid in the whole study population revealed negative correlation between these parameters, and this association remained statistically significant after controlling for gender (coefficient of partial correlation rp= -0.225, p = 0.003). Conclusions. Adiponectin and uric acid levels was similar in IGT and type 2 diabetes groups. Adiponectin levels were significantly lower whereas uric acid concentrations were statistically significantly higher in subjects with impaired glucose metabolism as compared to the healthy controls. Keywords: adiponectin, uric acid, insulin resistance, prediabetes, type 2 diabetes |
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