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Acta medica Lituanica

ISSN 1392-0138
ISSN 2029-4174 (online)

2008 m. Nr. 3

Host response to Human papilloma virus in cervical cancer patients
Birutė KAZBARIENĖ, Gražina PRASMICKIENĖ, Aurelija KRIKŠTAPONIENĖ, Živilė GUDLEVIČIENĖ, Janina DIDŽIAPETRIENĖ

Background. Disbalance of immune and antioxydative systems are among the risk factors activating Human papilloma virus (HPV) infection and development of cervical cancer. The aim of this study was to investigate functions of these systems in cervical cancer patients analyzing alterations related to the types of HPV infection.

Methods. 136 cervical cancer patients were tested for HPV infection. Parameters of cellular and humoral immunity were analyzed. The antioxydative system status was evaluated detecting the level of lipid peroxydation product malondialdehyde (MDA), the catalytic activity of antioxidant enzymes catalase (CAT) and superoxyde dismutase (SOD) and the amount of antioxidant vitamins A and E.

Results. In cervical cancer patients group infected with HPV types 16 or 18 five indices of immunity (CD4+, CD8+, CD19+, CD16+, IgM) were lower comparing with the corresponding parameters of HPV-negative patients. In HPV-positive (unidentified types) patients CD16+ and CD19+ were lower than in HPV-negative patients. In patients infected with HPV types 16 or 18 CD4+ and CD16+ were found to be lower if compared with the corresponding indices of HPV-positive (unidentified types) patients. No significant changes of the antioxydative system parameters were observed in patients infected by HPV types 16 or 18 comparing to the patients infected by HPV of unidentified types or to HPV-negative patients.

Conclusions. Alterations of immune system parameters of cervical cancer patients were determined by HPV infection. Antioxydative system parameters were found not to be changed significantly due to the infection.

Keywords: cervical cancer, HPV, antioxydative system, immune system

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