 ISSN 1392-0138 ISSN 2029-4174 (online) |
2008 m. Nr. 4 Serum levels of transforming growth factor β1 (TGF-β1) in patients with rheumatoid arthritis and Sjögren’s syndrome
Background. Autoimmune diseases, including rheumatoid arthritis (RA) and Sjögren’s syndrome, are characterized by loss of immunological tolerance to self-antigens. Transforming growth factor (TGF-β1) is a pleiotropic cytokine that regulates cell growth, adhesion, and differentiation in a wide variety of cell types. Studies of animal models and human patients have revealed a critical function for TGF-β1 in regulating leukocyte functions in autoimmune diseases. Measurement of TGF-β1 is becoming an important screening tool for identifying biomarkers of autoimmune diseases. The purpose of this study was to assess and to compare serum levels of TGF-β1 in patients with rheumatoid arthritis (RA), Sjögren’s syndrome secondary to rheumatoid arthritis (sSS + RA) and primary Sjögren’s syndrome (pSS). Material and methods. Sera were obtained from 23 patients with RA, 23 patients with sSS + RA, 23 patients with pSS and 20 healthy individuals. Serum levels of TGF-β1 were measured using the respective commercially available BIOSOURCE Immunoassay kit (BioSource International, Inc., USA). Results. Comparison of the serum levels of TGF-β1 in patients with RA, sSS + RA, pSS and healthy individuals showed significant differences of TGF-β1 concentration between four groups (respectively, 51736 ± 12483 pg/ml vs 32953 ± 3090 pg/ml vs 17500 ± 3773 pg/ml and vs 31600 ± 2040 pg/ml, p < 0.001). Conclusion. The appropriate serum levels of TGF-β1 may reflect an ongoing autoimmune inflammation in the different target organs. Keywords: transforming growth factor-β1, rheumatoid arthritis, Sjögren’s syndrome |
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