Biologija / Biology
 ISSN 1392-0146 ISSN 2029-0578 (online) |
2005 m. Nr. 1 Role of intracellular accumulation in the prooxidant
cytotoxicity of daunorubicin
Oxidative stress partly contributes to the cytotoxicity of the anticancer anthracycline daunorubicin in FLK and HL-60 cells. However, daunorubicin is 100–300 times more cytotoxic than the model quinone danthron possessing a similar reduction potential. This discrepancy may be explained by the high cell/medium partition coefficient of daunorubicin, 570 ± 40 (HL-60 cells) and 230 ± 30 (FLK cells) calculated using the fluorescence quenching method. The cell/medium partition coefficient for danthron is below 10.
Keywords: daunorubicin, intracellular accumulation, cytotoxicity, oxidative stress |
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