ISSN 1392-0146
ISSN 2029-0578 (online)
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2006 m. Nr. 3
Differential association of Nck family proteins with
PDGF receptor-β and Ras GTPase activating protein
V. Gurskienė,
M. Ger,
M. Valius
The Src homology (SH) domains are protein modules found in many different proteins. The Nck family proteins consist of Nck-α and Nck-β proteins composed entirely of SH2 and SH3 domains and have no any putative catal ytic domain. These proteins act as adaptors by linking tyrosine-phosphorylated proteins to other signaling molecules. Here we show that Nck-β associates with the ligand-stimulated platelet-derived growth factor (PDGF) receptor-β and Ras GTPase-activating protein (RasGAP) in vivo. Nck-β interaction with RasGAP is constant, but also increases after PDGF receptor-β stimulation. In contrast, Nck-α does not interact with ligand-activated PDGF receptor-β, but constantly associates with RasGAP.
Keywords: PDGF receptor-β, RasGAP, Nck
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