Ribonuclease P (RNase P) removes 5’-leader sequences from precursor tRNAs and occurs in all three phylogenetic domains. The enzyme is universally composed of both protein and RNA moieties. RNase P requires both RNA and protein subunits for functioning in vivo. Little is known about the RNase P from ciliated protozoan. In this study, we have identified a Tetrahymena pyriformis sequence showing a homoly to Pop1, the largest protein subunit of RNase P. cDNA containing a complete coding sequence for the protein was cloned. We report the cloning and characterization of the gene encoding RNase P RNA and the present secondary structure modelį of the predicted RNA.

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2011 - Vol.57
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