Chemija / Chemistry
 ISSN 0235-7216 ISSN 2424-4538 (online) |
2007 m. Nr. 1 Synthesis and properties of some new derivatives of
4–succinamoyl piperazine–2,6–dione
A new series of piperazine-2,6 dione derivatives containing N-substituted succinamic acid residue was synthesized and tested for the analgesic activity. 4-[N-(4-methylphenyl)succinamoyl]-piperazine-2,6-dione showed the best analgesic activity. Keywords: piperazine-2,6-dione, succinamic acid, synthesis, acylation, analgesic effect |
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