Determination of different metals (K, Na, Mg, Ca, Sr, Cr, Mn, Fe, Cu, Zn, Cd, Ni, Co and Pb) by flame atomic absorption spectrometry (FAAS) and of liver enzymes (ALT, AST, ALP and GGT) by catalytic reactions in human blood plasma from non-infected patients, those infected with hepatitis C virus and from patients with viral C cirrhosis has been performed. The results demonstrated that the analytical procedures could be successfully applied for a rapid and accurate determination of metals and enzymes in different blood samples. A negligible correlation was found among the concentrations of macroand microelements and liver enzymes in blood plasma samples for different patients. In the later stages of viral liver disease, the concentration of enzymes becomes lower. The aim of the present study was to investigate, to our knowledge for the first time, the correlation between the levels of different metals and the concentration of liver enzymes (ALT, AST, ALP and GGT) in blood plasma samples from patients with hepatitis C virus and patients with viral C cirrhosis.

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