Chemija / Chemistry
 ISSN 0235-7216 ISSN 2424-4538 (online) |
2012 m. Nr. 1 Synthesis of azolethione derivatives from 3-(phenylamino)propanehydrazide
Heating of 3-(phenylamino)propanehydrazide with ethyl xanthogenate provided potassium salt of carbodithioate, which under the action of hydrochloric or sulphuric
acid was cyclized to 5-[2-(phenylamino)ethyl]-2,3-dihydro-1,3,4-oxadiazole-2-thione or 5-[2-(phenylamino)ethyl]-2,3-dihydro-1,3,4-thiadiazole-2-thione. In the reaction with phenacyl bromide it was transformed into N-(4-phenyl-2-thioxo-2,3-dihydro-1-, 3-tiazol-3-yl)-3-(phenylamino)propanamide and, under treatment with hydrazine, gave 4-amino-3-[2-(phenylamino)ethyl]-4,5-dihydro-1H-1,2,4-triazole-5-thione, which subsequently underwent condensation reaction with phenacyl bromide to give N-[2-(6- phenyl-7H-[1,2,4]triazol[3,4-b][1,3,4]-3-yl)ethyl]aniline. Keywords: hydrazide, 1,2,4-triazolethione, 1,3,4-oxadiazolethione, 1,3,4-thiadiazolethione, tetraazabicyclononatriene, cyclization |
Issues:
2017 - Vol.28 No. 1, No. 2, No. 3, No. 4 2016 - Vol.27 No. 1, No. 2, No. 3, No. 4 2015 - Vol.26 No. 1, No. 2, No. 3, No. 4 2014 - Vol.25 No. 1, No. 2, No. 3, No. 4 2013 - Vol.24 No. 1, No. 2, No. 3, No. 4 2012 - Vol.23 No. 1, No. 2, No. 3, No. 4 2011 - Vol.22 No. 1, No. 2, No. 3, No. 4 2010 - Vol.21 No. 1, No. 2-4 2009 - Vol.20 No. 1, No. 2, No. 3, No. 4 2008 - Vol.19 No. 1, No. 2, No. 3-4 2007 - Vol.18 No. 1, No. 2, No. 3, No. 4 2006 - Vol.17 No. 1, No. 2-3, No. 4 2005 - Vol.16 No. 1, No. 2, No. 3-4 2004 - Vol.15 No. 1, No. 2, No. 3, No. 4 2003 - Vol.14 No. 1, No. 2, No. 3, No. 4 2002 - Vol.13 No. 1, No. 2, No. 3, No. 4 2001 - Vol.12 No. 1, No. 2, No. 3, No. 4 |