Chemija / Chemistry
 ISSN 0235-7216 ISSN 2424-4538 (online) |
2012 m. Nr. 2 Synthesis and antimicrobial studies of novel (2-benzylidene)-
phenylureido-thiazolopyrimidine derivatives
A new series of ethyl 2-(substitutedbenzylidene)-5-methyl-3-oxo-7-(4-(3-phenylureido) phenyl)-3,7-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate derivatives (7a–k) were synthesized. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, LCMS mass and C, H, N analyses. All newly synthesized compounds were screened for their in vitro antibacterial activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Streptococcus pyogenes and for antifungal activity against Aspergillus flavus, Aspergillus fumigatus, Candida albicans, Penicillium marneffei and Mucor. Compounds 7b, 7e, 7f, 7g, 7h and 7j showed excellent in vitro antibacterial activity and antifungal activity compared with the standard drugs.
Keywords: 2-benzylidene-phenylureido-thiazolopyrimidine, antibacterial, antifungal activities |
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