Chemija / Chemistry
 ISSN 0235-7216 ISSN 2424-4538 (online) |
2012 m. Nr. 3 A facile route for the preparation of disubstituted 1,3,4-oxadiazoles from furfural, carboxylic acids, and secondary amines in the presence of N-isocyaniminotriphenylphosphorane
A simple method has been developed for four-component synthesis of disubstituted 1,3,4-oxadiazoles using N-isocyaniminotriphenylphosphorane, a secondary amine, carboxylic acid, and furfural in CH2Cl2 by a Ugi-4CR/aza-Wittig sequence at room temperature in fairly high yields without using any catalyst or activation. The procedure provides an alternative method to the preparation of fully substituted 1,3,4-oxadiazoles.
Keywords: N-isocyaniminotriphenylphosphorane, furfural, carboxylic acid, 1,3,4-oxadiazole, aza-Wittig reaction, secondary amine |
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