Chemija / Chemistry
 ISSN 0235-7216 ISSN 2424-4538 (online) |
2013 m. Nr. 1 Synthesis and antimicrobial activity of 1,3-disubstituted pyrrolidinones with hydrazone and naphthoquinone moieties
1-(4-Aminophenyl)-5-oxo-3-pyrrolidinecarbohydrazide was converted into a series of new hydrazone derivatives and compounds, containing pyrazole, pyrrole, and 4-substituted benzene moieties. Reaction of 2,3-dichloro-1,4-naphthoquinone with the obtained compounds as well as with 5-oxo-1-(4-aminophenyl)pyrrolidine-3-carboxylic acid and its ester provided derivatives of 3-chloro-1,4-naphthoquinone, some of which exhibited good antifungal activities at low concentrations against Candida tenuis and Aspergillus niger. Keywords: hydrazone derivatives, 3-chloro-1,4-naphthoquinone derivatives, pyrazole, pyrrole, antifungal activity |
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