Chemija / Chemistry
 ISSN 0235-7216 ISSN 2424-4538 (online) |
2015 m. Nr. 4 Synthesis of 5-(arylaminomethyl)furo[2,3-d]pyrimidine derivatives and cytotoxicity evaluation against some human solid tumor cell lines
5-(Arylaminomethyl)furo[2,3-d]pyrimidines were synthesized via the Mitsunobu reaction from 5-hydroxymethylfuro[2,3-d]pyrimidine derivative and N-sulphonylanilines as acidic components of the Mitsunobu reaction. Substituents on the phenyl moiety, the methylenamino bridge and the 2nd position of furo[2,3-d]pyrimidine scaffold were marked as of particular interest, so synthesis protocols for modification of these positions were suggested. The selected compounds were evaluated in vitro against a panel of six human solid tumor cell lines: A2780 (ovarian), HBL-100 (breast), HeLa (cervix), SW (non-small cell lung), T47D (breast) and WiDr (colon).
Keywords: furo[2,3-d]pyrimidines, Mitsunobu reaction, nitrogen heterocycles, C–N bond formation, anti-cancer drugs |
Issues:
2017 - Vol.28 No. 1, No. 2, No. 3, No. 4 2016 - Vol.27 No. 1, No. 2, No. 3, No. 4 2015 - Vol.26 No. 1, No. 2, No. 3, No. 4 2014 - Vol.25 No. 1, No. 2, No. 3, No. 4 2013 - Vol.24 No. 1, No. 2, No. 3, No. 4 2012 - Vol.23 No. 1, No. 2, No. 3, No. 4 2011 - Vol.22 No. 1, No. 2, No. 3, No. 4 2010 - Vol.21 No. 1, No. 2-4 2009 - Vol.20 No. 1, No. 2, No. 3, No. 4 2008 - Vol.19 No. 1, No. 2, No. 3-4 2007 - Vol.18 No. 1, No. 2, No. 3, No. 4 2006 - Vol.17 No. 1, No. 2-3, No. 4 2005 - Vol.16 No. 1, No. 2, No. 3-4 2004 - Vol.15 No. 1, No. 2, No. 3, No. 4 2003 - Vol.14 No. 1, No. 2, No. 3, No. 4 2002 - Vol.13 No. 1, No. 2, No. 3, No. 4 2001 - Vol.12 No. 1, No. 2, No. 3, No. 4 |