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Chemija / Chemistry

ISSN 0235-7216
ISSN 2424-4538 (online)

2015 m. Nr. 4

Synthesis of 5-(arylaminomethyl)furo[2,3-d]pyrimidine derivatives and cytotoxicity evaluation against some human solid tumor cell lines
Gražina PETRAITYTĖ, Viktoras MASEVIČIUS

5-(Arylaminomethyl)furo[2,3-d]pyrimidines were synthesized via the Mitsunobu reaction from 5-hydroxymethylfuro[2,3-d]pyrimidine derivative and  N-sulphonylanilines as acidic components of the Mitsunobu reaction. Substituents on the phenyl moiety, the methylenamino bridge and the 2nd position of furo[2,3-d]pyrimidine scaffold were marked as of particular interest, so synthesis protocols for modification of these positions were suggested. The selected compounds were evaluated in vitro against a panel of six human solid tumor cell lines: A2780 (ovarian), HBL-100 (breast), HeLa (cervix), SW (non-small cell lung), T47D (breast) and WiDr (colon).

Keywords: furo[2,3-d]pyrimidines, Mitsunobu reaction, nitrogen heterocycles, C–N bond formation, anti-cancer drugs

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