A series of novel N,N-disubstituted 2-aminothiazole derivatives were synthesized by the Hantzsch reaction from 3-[(1-naphthyl)carbamothioylamino]propanoic acid and α-halocarbonyl compounds. With the help of various chemical transformations of the obtained compounds, new variously functionalized 2-aminothiazole derivatives were synthesized. Some of them were tested for their antibacterial properties against gram-negative non-spore-forming rods of Rhizobium radiobacter.

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