 ISSN 0235-7216 ISSN 2424-4538 (online) |
2009 m. Nr. 3 Determination of low-residue benzodiazepine, lorazepam, in environmental water samples by suspended droplet microextraction and high performance liquid chromatography-diod array detector
Three-phase liquid-phase microextraction (LLLME) was developed for high performance liquid chromatography and capillary electrophoresis. The new branch of this mode, entitled suspended droplet liquid phase microextraction (SD-LPME), involves the use of a suspended droplet of an aqueous solvent. In this technique, the droplet is floated freely in the surface-center of an immiscible organic solvent, which has been laid on the surface of the aqueous sample while being agitated by a stirring bar. The performance of this technique is demonstrated in the determination of one of benzodiazepines, lorazepam, which is extracted into a single drop of aqueous solution. SD-LPME has provided good enrichment (645-fold), but relatively poor reproducibility: RSD%: 5.04, n = 5 (primarily due to repeated manual manipulation), simplicity, relatively fast extraction and back-extraction times (30.0 and 60.0 seconds, respectively). This method has allowed a direct transfer of the extracted analyte into a high performance liquid chromatography-diod array detector (HPLC-DAD). Keywords: HPLC-DAD, suspended droplet, liquid phase microextraction, lorazepam, aqueous samples |
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