 ISSN 0235-7224 ISSN 2029-0586 (online) |
2010 m. Nr. 3-4 Induction of micronuclei and other nuclear abnormalities in blue mussels Mytilus edulis after 1-, 2-, 4- and 8-day treatment with crude oil from the North Sea
The genotoxicity and cytotoxicity of crude oil processed from the Statfjord B platform in the North Sea were studied in gills of blue mussels (Mytilus edulis), exposed to 0.5 ppm concentration of the dispersed oil for 1, 2, 4 and 8 days. Induction of micronuclei (MN) and nuclear buds (NB) was assessed as the crude oil genotoxicity endpoints; induction of fragmented-apoptotic (FA) and bi-nucleated (BN) cells indicated the cytotoxicity potential of the oil. Time-related MN elevation incidences were detected in all experimental groups compared to the control group of mussels. The elevation of micronuclei increased progressively with increasing the duration of exposure – from 1.9-fold after 1 day to 2.4-fold after 8 days of exposure. There was no significant occurrence of nuclear buds in the experimental groups. A significant induction of fragmented-apoptotic cells (P = 0.0115) was detected in M. edulis gills after a 4-day exposure and of bi-nucleated cells after an 8-day treatment (P = 0.0232). Keywords: micronuclei, nuclear abnormalities, crude oil, blue mussel |
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